Comparison of the Serum Concentration of Zinc in Patients With Bronchiectasis and Control Group

نویسندگان

  • Seyed Ali JavadMoosavi
  • Shahab Shahabi Shahmiri
  • Elyas Mostafapour
  • Mohammad Purfakharan
  • Mehran Zamanzadeh
  • Seyed Mohammad Fereshtehnejad
  • Hanieh Raji
چکیده

BACKGROUND Bronchiectasis is an abnormal and permanent dilatation of bronchi. Infection plays a major role in causing and perpetuating bronchiectasis, as reducing the microbial load and attendant mediators are cornerstone of therapy. Zinc, as an integral micronutrient is involved in the immune reactions including response to infection. In several previous studies, mild zinc deficiency has been described in many infectious diseases such as abscess, cellulitis, chronic diarrhea, pneumonia, tuberculosis (TB), etc. OBJECTIVES The purpose of this study was to determine serum zinc level in a series of patients suffering from bronchiectasis and to compare it with healthy control group. PATIENTS AND MATERIALS This analytical cross-sectional study was performed on thirty four patients with proven bronchiectasis and twenty nine healthy control subjects referred to Rasoul-e-Akram Hospital, Tehran, Iran, between March 2005 and March 2007. Serum concentration of the zinc was measured for all of the subjects and other information was completed according to their medical records. Both groups (case and control) were frequently matched regarding their age groups. RESULTS Patients included 11 (32.4%) males and 23 (67.6%) females with the average age of 55.03 (SD = 17.06) yr. The mean level of serum zinc in the case and control groups were 94.06 (SD = 20/96) mcg/dl and 103.7 (SD = 11.96) mcg/dl, respectively. Independent T-test analysis showed that serum zinc concentration in the case group of bronchiectasis patients was significantly lower than control group (P = 0.02). CONCLUSIONS The results of our study show that serum zinc level in bronchiectasis patients was lower than the control group and the difference was statistically significant. It seems that the use of zinc supplement can reduce progression of the infectious disease regarding its role in improving the immune system reactions and some unknown mechanisms. Therefore, prophylactic and therapeutic use of zinc must be evaluated in further trials.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of Serum Concentration of Lead, Copper, Zinc and Cadmium in Gastric Adenocarcinoma and Non-cancerous Patients in Valiasr Hospital of Zanjan in 1397

Back ground: Gastric cancer is an important, prevalant and second most fatal cancer in the world. Previous studies show heavy metals have various roles in human health. Heavy metals are known to be associated with various cancers but their function in gastric adenocarcinoma is unclear. In this study we examined serum level of these metals in gastric adenocarcinoma patients compared to control g...

متن کامل

Determination of the serum level of aluminum & zinc in hemodialysis patients in Kerman,Iran

Dialysis is one of the effective methods which has been used since 1955 for the treatment of patients suffering from renal failure( more often of its chronic type). The dialysis results in the elimination of waste materials like urea and creatinine from the body, on the other hand, it can affect the serum contamination of the dialysis fluid. Aluminium is one of trace elements which its serum le...

متن کامل

Measurement of serum zinc level in adult patients with cutaneous warts and comparison with the healthy control group

Background: Human papillomavirus (HPV) is a large group of DNA viruses that cause skin and mucosal warts. Zinc is used in the treatment of skin diseases. Zinc has been used in the treatment of various skin and systemic diseases. Warts are benign proliferation of the skin and mucosa. The prevalence of skin warts is higher in children and its peak is in adolescence and then decreases with age. So...

متن کامل

Comparison of Serum Zinc Levels in Children with Epilepsy and Febrile Convulsions

Introduction: Epilepsy is one of the most common and chronic neurological diseases in children. The prevalence of this disease among children in Iran is estimated at 5%, which is higher than the average prevalence in other countries. Several studies have been done on the role of trace elements in serum and its role in the pathogenesis of epilepsy, but there is still little information on the ro...

متن کامل

The Relationship between Copper & Zinc Concentration and Free Radical Markers in Copper Industry Workers

Introduction: Copper and zinc play a key role in oxidative reactions and in vivo studies have shown their different effects. In this study we examined the influence of exposure to copper and zinc on catalase and superoxide dismutase (SOD) activities in erythrocytes, total serum antioxidant capacity and malondiadehyde (MDA) production of copper industry workers. Methods: In the present study...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 15  شماره 

صفحات  -

تاریخ انتشار 2013